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Nanomedicine efficacy and toxicity is influenced by how nanoparticles distribute in the human body. Provide a detailed summary of the main processes defining nanoparticle pharmacokinetics. 

1. Nanomedicine efficacy and toxicity is influenced by how nanoparticles distribute in the human body. Provide a detailed summary of the main processes defining nanoparticle pharmacokinetics.
2. The enhanced permeation and retention effect (EPR) is important for cancer nanomedicines. Describe the EPR effect and discuss how nanomedicines can be designed to achieve targeting using this effect.
3.    Nanomaterials may be designed to either interact with the immune system or avoid it entirely. Discuss approaches that may be employed to avoid/interact with the immune system. Provide examples of diseases where these interactions may be beneficial/problematic
4. Nanoparticles have a number of physico-chemical characteristics that may influence how they interact with certain biological systems, either favorably or unfavorably. Give three examples of physico-chemical characteristics explaining how these characteristics may be related to nanoparticle interaction with biological systems.

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